Elevated RANTES levels are associated with increased risk of cerebral atherosclerotic stenosis.

ABSTRACT:

Background

Cerebral atherosclerotic stenosis (CAS) is a significant factor in the development of acute ischemic stroke (AIS). Previous studies have reported that cytokines are involved in atherosclerotic diseases, although the relationship between serum levels of the chemokine RANTES (regulated on activation, normal T-cell expressed and secreted) and the presence of CAS remains unclear.

Methods

In total, 127 participants (65 non-AIS controls and 62 patients with AIS) were involved in this study. CAS was defined as the presence of ≥ 50% stenosis in major intracranial or extracranial artery by a Digital Substraction Angiography (DSA) examination, and we classified all participants into four groups according to stroke and CAS status. Serum concentrations of 8 cytokines, includi

SUBMITTER: Guo Y 

PROVIDER: S-EPMC9875531 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature