Polygenic score for cigarette smoking is associated with ever electronic-cigarette use in a college-aged sample.

ABSTRACT:

Background and aims

Electronic cigarette use has escalated rapidly in recent years, particularly among youth. Little is known about the genetic influences on e-cigarette use. This study aimed to determine whether genetic risk for regular use of combustible cigarettes or for number of cigarettes smoked per day confers risk for ever e-cigarette use or frequency of e-cigarette use.

Design, setting, participants, and measurements

We used data from 9541 young adults from the Spit for Science longitudinal cohort study (2011-2019). Polygenic scores (PGS) of regular combustible cigarette use (PGS-RCU) and cigarettes per day (PGS-CPD) were constructed using summary statistics from the two largest available genome-wide association study (GWAS) meta-analysis of European ancestry and Ea

SUBMITTER: Cooke ME 

PROVIDER: S-EPMC9875558 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature