Prognostic value of Siglec-15 expression in patients with solid tumors: A meta-analysis.

ABSTRACT:

Background

Siglec-15 is expressed in a variety of cancers. However, the role of Siglec-15 in the prognosis of cancer patients remains controversial. Therefore, we conducted a meta-analysis to clarify the potential prognostic value of Siglec-15 in solid tumors.

Methods

The PubMed, Web of Science, Embase and CNKI databases were comprehensively searched to identify studies assessing the effect of Siglec-15 on the survival of cancer patients. Hazard ratios (HRs) with 95% confidence intervals (CIs) for overall survival (OS), progression-free survival (PFS) and disease-specific survival (DSS) from individual studies were evaluated.

Results

The data from 13 observational studies consisting of 1376 patients were summarized. Elevated baseline Siglec-15 expression was significa

SUBMITTER: Jiang KY 

PROVIDER: S-EPMC9875589 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature