Effects of acupuncture on cartilage p38MAPK and mitochondrial pathways in animal model of knee osteoarthritis: A systematic evaluation and meta-analysis.

ABSTRACT:

Background

Most previous studies on acupuncture in the treatment of knee osteoarthritis (KOA) have focused on improving functional efficacy and safety, while related mechanisms have not been systematically reviewed. Acupuncture modulates cytokines to attenuate cartilage extracellular matrix degradation and apoptosis, key to the pathogenesis of KOA, but the mechanisms are complex.

Objectives

The purpose of this study is to assess the efficacy of acupuncture quantitatively and summarily in animal studies of KOA.

Methods

Nine databases including PubMed, Embase, Web of Science (including Medline), Cochrane library, Scopus, CNKI, Wan Fang, and VIP were searched to retrieve animal studies on acupuncture interventions in KOA published since the inception of the journal. Rele

SUBMITTER: Ye JN 

PROVIDER: S-EPMC9875597 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature