Towards biomarker-based optimization of deep brain stimulation in Parkinson's disease patients.

ABSTRACT:

Background

Subthalamic deep brain stimulation (DBS) is an established therapy to treat Parkinson's disease (PD). To maximize therapeutic outcome, optimal DBS settings must be carefully selected for each patient. Unfortunately, this is not always achieved because of: (1) increased technological complexity of DBS devices, (2) time restraints, or lack of expertise, and (3) delayed therapeutic response of some symptoms. Biomarkers to accurately predict the most effective stimulation settings for each patient could streamline this process and improve DBS outcomes.

Objective

To investigate the use of evoked potentials (EPs) to predict clinical outcomes in PD patients with DBS.

Methods

In ten patients (12 hemispheres), a monopolar review was performed by systematically stimu

SUBMITTER: Peeters J 

PROVIDER: S-EPMC9875598 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature