A longitudinal analysis of early lung function trajectory in survivors of childhood Hodgkin lymphoma.

ABSTRACT:

Background

Childhood Hodgkin lymphoma survivors suffer from long-term effects decades after treatment completion with a prevalence of pulmonary dysfunction of up to 65.2%.

Aims

This study explored the early trajectory of pulmonary function in pediatric cancer patients with Hodgkin lymphoma who received pulmonary toxic therapy.

Methods and results

In this single-center, 20-year retrospective cohort study, we included patients who were <18 years old at diagnosis of Hodgkin lymphoma between January 1994 and December 2014, and received bleomycin or thoracic radiation. We measured pulmonary function and reported on percent predicted values for forced expiratory volume in 1 s, total lung capacity, and diffusing capacity of the lungs. We used linear mixed models to identify

SUBMITTER: Zheng K 

PROVIDER: S-EPMC9875613 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature