Quantification of spatial pharmacogene expression heterogeneity in breast tumors.

ABSTRACT:

Background

Chemotherapeutic drug concentrations vary across different regions of tumors and this is thought to be involved in development of chemotherapy resistance. Insufficient drug delivery to some regions of the tumor may be due to spatial differences in expression of genes involved in the disposition, transport, and detoxification of drugs (pharmacogenes). Therefore, in this study, we analyzed the spatial expression of 286 pharmacogenes in six breast cancer tissues using the recently developed Visium spatial transcriptomics platform to (1) determine if these pharmacogenes are expressed heterogeneously across tumor tissue and (2) to determine which pharmacogenes have the most spatial expression heterogeneity.

Methods and results

The spatial transcriptomics technology seq

SUBMITTER: Powell NR 

PROVIDER: S-EPMC9875649 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature