Differential vulnerability of anterior cingulate cortex cell types to diseases and drugs.

ABSTRACT: In psychiatric disorders, mismatches between disease states and therapeutic strategies are highly pronounced, largely because of unanswered questions regarding specific vulnerabilities of different cell types and therapeutic responses. Which cellular events (housekeeping or salient) are most affected? Which cell types succumb first to challenges, and which exhibit the strongest response to drugs? Are these events coordinated between cell types? How does disease and drug effect this coordination? To address these questions, we analyzed single-nucleus-RNAseq (sn-RNAseq) data from the human anterior cingulate cortex-a region involved in many psychiatric disorders. Density index, a metric for quantifying similarities and dissimilarities across functional profiles, was employed to identify comm

SUBMITTER: Smail MA 

PROVIDER: S-EPMC9875728 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature