Harms in Systematic Reviews Paper 3: Given the same data sources, systematic reviews of gabapentin have different results for harms.

ABSTRACT:

Objective

In this methodologic study (Part 2 of 2), we examined the overlap in sources of evidence and the corresponding results for harms in systematic reviews for gabapentin.

Study design & setting

We extracted all citations referenced as sources of evidence for harms of gabapentin from 70 systematic reviews, as well as the harms assessed and numerical results. We assessed consistency of harms between pairs of reviews with a high degree of overlap in sources of evidence (>50%) as determined by corrected covered area (CCA).

Results

We found 514 reports cited across 70 included reviews. Most reports (244/514, 48%) were not cited in more than one review. Among 18 pairs of reviews, we found reviews had differences in which harms were assessed and their choice to meta-an

SUBMITTER: Qureshi R 

PROVIDER: S-EPMC9875741 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature