Physical inactivity by tail suspension alters markers of metabolism, structure, and autophagy of the mouse heart.

ABSTRACT: Sedentary behavior has become ingrained in our society and has been linked to cardiovascular diseases. Physical inactivity is the main characteristic of sedentary behavior. However, its impact on cardiovascular disease is not clear. Therefore, we investigated the effect of physical inactivity in an established mouse model on gene clusters associated with cardiac fibrosis, electrophysiology, cell regeneration, and tissue degradation/turnover. We investigated a sedentary group (CTR, n = 10) versus a tail suspension group (TS, n = 11) that caused hindlimb unloading and consequently physical inactivity. Through histological, protein content, and transcript analysis approaches, we found that cardiac fibrosis-related genes partly change, with significant TS-associated increases in Tgfb1, but wit

SUBMITTER: Rojo-Garcia AV 

PROVIDER: S-EPMC9875748 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature