Soy-Based Infant Formula Feeding and Uterine Fibroid Development in a Prospective Ultrasound Study of Black/African-American Women.

ABSTRACT:

Background

Uterine fibroids are highly prevalent, benign tumors. They are the leading indication for hysterectomy, and Black women are disproportionally burdened. Soy-based infant formula contains phytoestrogens, and exposure during sensitive developmental windows may adversely affect the developing uterus; early phytoestrogen treatment in rodent studies led to detrimental uterine effects, including increased fibroid risk in Eker rats. Limited epidemiological studies also have suggested increased fibroid development with soy formula infant feeding.

Objective

The goal of this study was to examine the association between soy formula feeding in infancy and fibroid development in adulthood.

Methods

We evaluated this association among 1,610 Black/African-American women age

SUBMITTER: Langton CR 

PROVIDER: S-EPMC9875846 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature