Ontology highlight
ABSTRACT:
SUBMITTER: Kim R
PROVIDER: S-EPMC9875862 | biostudies-literature | 2022 Dec
REPOSITORIES: biostudies-literature
Kim Rina R Hashimoto Ayumi A Markosyan Nune N Tyurin Vladimir A VA Tyurina Yulia Y YY Kar Gozde G Fu Shuyu S Sehgal Mohit M Garcia-Gerique Laura L Kossenkov Andrew A Gebregziabher Bereket A BA Tobias John W JW Hicks Kristin K Halpin Rebecca A RA Cvetesic Nevena N Deng Hui H Donthireddy Laxminarasimha L Greenberg Andrew A Nam Brian B Vonderheide Robert H RH Nefedova Yulia Y Kagan Valerian E VE Gabrilovich Dmitry I DI
Nature 20221116 7939
Ferroptosis is a non-apoptotic form of regulated cell death that is triggered by the discoordination of regulatory redox mechanisms culminating in massive peroxidation of polyunsaturated phospholipids. Ferroptosis inducers have shown considerable effectiveness in killing tumour cells in vitro, yet there has been no obvious success in experimental animal models, with the notable exception of immunodeficient mice<sup>1,2</sup>. This suggests that the effect of ferroptosis on immune cells remains p ...[more]