Mining the Plasma Proteome for Insights into the Molecular Pathology of Pulmonary Arterial Hypertension.

ABSTRACT: Rationale: Pulmonary arterial hypertension (PAH) is characterized by structural remodeling of pulmonary arteries and arterioles. Underlying biological processes are likely reflected in a perturbation of circulating proteins. Objectives: To quantify and analyze the plasma proteome of patients with PAH using inherited genetic variation to inform on underlying molecular drivers. Methods: An aptamer-based assay was used to measure plasma proteins in 357 patients with idiopathic or heritable PAH, 103 healthy volunteers, and 23 relatives of patients with PAH. In discovery and replication subgroups, the plasma proteomes of PAH and healthy individuals were compared, and the relationship to transplantation-free survival in PAH was determined. To examine causal relationships to

SUBMITTER: Harbaum L 

PROVIDER: S-EPMC9875902 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature