Motor progression marker for newly diagnosed drug-naive patients with Parkinson's disease: A resting-state functional MRI study.

ABSTRACT: The effective early prediction of clinical outcomes of Parkinson's disease (PD) is of great significance in the implementation of appropriate interventions. We aimed to propose a method based on the use of baseline resting-state functional characteristics (i.e., fractional amplitude of low-frequency fluctuations, fALFF) to predict motor progression in PD patients. Resting-state functional magnetic resonance imaging was performed on 48 newly-diagnosed drug-naïve PD patients and 27 age- and sex- matched healthy controls (HCs). Two PD subgroups were defined with different annual increase of Unified PD Rating Scale Part III motor scores. Least absolute shrinkage and selection operator regression analysis was performed to explore the baseline region-functional indicators for PD discrimination a

SUBMITTER: Hou Y 

PROVIDER: S-EPMC9875914 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature