Reversal of neurovascular decoupling and cognitive impairment in patients with end-stage renal disease during a hemodialysis session: Evidence from a comprehensive fMRI analysis.

ABSTRACT: Neurovascular (NV) decoupling is a potential neuropathologic mechanism of cognitive impairment in patients with end-stage renal disease (ESRD). Hemodialysis improves cognitive impairment at 24 h post-dialysis, which suggests a potential neuroprotective effect of hemodialysis treatment on the brain. We investigated the effects of hemodialysis treatment on the reversal of NV decoupling associated with cognitive improvement. A total of 39 patients with ESRD and 39 healthy controls were enrolled. All patients were imaged twice during a dialysis session: before hemodialysis (T1_pre-dialysis ) and at 24 h after dialysis (T2_{post-dialysis} ). The healthy controls were imaged once. NV coupling was characterized based on correlation coefficients between four types of blood oxygen

SUBMITTER: Li P 

PROVIDER: S-EPMC9875915 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature