Investigations of hypoxia-induced deoxyhemoglobin as a contrast agent for cerebral perfusion imaging.

ABSTRACT: The assessment of resting perfusion measures (mean transit time, cerebral blood flow, and cerebral blood volume) with magnetic resonance imaging currently requires the presence of a susceptibility contrast agent such as gadolinium. Here, we present an initial comparison between perfusion measures obtained using hypoxia-induced deoxyhemoglobin and gadolinium in healthy study participants. We hypothesize that resting cerebral perfusion measures obtained using precise changes of deoxyhemoglobin concentration will generate images comparable to those obtained using a clinical standard, gadolinium. Eight healthy study participants were recruited (6F; age 23-60). The study was performed using a 3-Tesla scanner with an eight-channel head coil. The experimental protocol consisted of a high-resoluti

SUBMITTER: Sayin ES 

PROVIDER: S-EPMC9875930 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature