Assessing the interaction effects of brain structure longitudinal changes and life environmental factors on depression and anxiety.

ABSTRACT: Disrupted brain structures and several life environmental factors have been shown to influence depression and anxiety, but their interactions with anxiety and depression remain elusive. Genome-wide association study datasets of 15 brain structure longitudinal changes (N = 15,640) were obtained from the published study. Genotype and phenotype-related data of depression, anxiety, and life environmental factors (including smoking, alcohol drinking, coffee intake, maternal smoking, physical activity, vitamin D, insomnia, sleep duration, and family satisfaction) were collected from UK Biobank. We calculated the polygenic risk scores (PRS) of 15 brain structure changes and then conducted linear regression analyses to explore the interactions of brain structure changes and life environmental fact

SUBMITTER: Yang X 

PROVIDER: S-EPMC9875931 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature