Preoperative Plasma Tau-PT217 and Tau-PT181 Are Associated With Postoperative Delirium.

ABSTRACT:

Objective

This study aims to identify blood biomarkers of postoperative delirium.

Background

Phosphorylated tau at threonine 217 (Tau-PT217) and 181 (Tau-PT181) are new Alzheimer disease biomarkers. Postoperative delirium is associated with Alzheimer disease. We assessed associations between Tau-PT217 or Tau-PT181 and postoperative delirium.

Methods

Of 491 patients (65 years old or older) who had a knee replacement, hip replacement, or laminectomy, 139 participants were eligible and included in the analysis. Presence and severity of postoperative delirium were assessed in the patients. Preoperative plasma concentrations of Tau-PT217 and Tau-PT181 were determined by a newly established Nanoneedle technology.

Results

Of 139 participants (73±6 years old, 55% femal

SUBMITTER: Liang F 

PROVIDER: S-EPMC9875943 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature