Inhibition is a prevalent mode of activity in the neocortex around awake hippocampal ripples in mice.

ABSTRACT: Coordinated peri-ripple activity in the hippocampal-neocortical network is essential for mnemonic information processing in the brain. Hippocampal ripples likely serve different functions in sleep and awake states. Thus, the corresponding neocortical activity patterns may differ in important ways. We addressed this possibility by conducting voltage and glutamate wide-field imaging of the neocortex with concurrent hippocampal electrophysiology in awake mice. Contrary to our previously published sleep results, deactivation and activation were dominant in post-ripple neocortical voltage and glutamate activity, respectively, especially in the agranular retrosplenial cortex (aRSC). Additionally, the spiking activity of aRSC neurons, estimated by two-photon calcium imaging, revealed the existenc

SUBMITTER: Karimi Abadchi J 

PROVIDER: S-EPMC9876570 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature