Weight cycling induces innate immune memory in adipose tissue macrophages.

ABSTRACT:

Introduction

Weight loss improves obesity-associated diabetes risk. However, most individuals regain weight, which worsens the risk of developing diabetes and cardiovascular disease. We previously reported that male mice retain obesity-associated immunological changes even after weight loss, suggesting that immune cells may remember the state of obesity. Therefore, we hypothesized that cycles of weight gain and loss, otherwise known as weight cycling, can induce innate memory in adipose macrophages.

Methods

Bone marrow derived macrophages were primed with palmitic acid or adipose tissue conditioned media in a culture model of innate immune memory. Mice also put on low fat or high fat diets over 14-27 weeks to induce weight gain, weight loss, and weight cycling.

Results

SUBMITTER: Caslin HL 

PROVIDER: S-EPMC9876596 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature