Histone methyltransferase Smyd2 drives vascular aging by its enhancer-dependent activity.

ABSTRACT:

Background

Vascular aging is one of the important factors contributing to the pathogenesis of cardiovascular diseases. However, the systematic epigenetic regulatory mechanisms during vascular aging are still unclear. Histone methyltransferase SET and MYND domain-containing protein 2 (Smyd2) is associated with multiple diseases including cancer and inflammatory diseases, but whether it is involved in endothelial cell senescence and aging-related cardiovascular diseases has not been directly proved. Thus, we aim to address the effects of Smyd2 on regulating angiotensin II (Ang II)-induced vascular endothelial cells (VECs) senescence and its epigenetic mechanism.

Methods and results

The regulatory role of Smyd2 in Ang II-induced VECs senescence was confirmed by performing loss

SUBMITTER: Su Z 

PROVIDER: S-EPMC9876634 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature