Dataset Information

A case-control study coupling with meta-analysis elaborates decisive association between IGF-1 rs35767 and osteoporosis in Asian postmenopausal females.

ABSTRACT:

Background

Osteoporosis (OP) is prevalent in postmenopausal women. Several studies investigated the association between IGF-1 polymorphisms and OP among postmenopausal females with conflicting outcomes.

Objective

To investigate whether the IGF-1 (rs35767, rs2288377, rs5742612) were associated with OP in postmenopausal females.

Methods

In case-control study, 95 OP cases and 222 healthy controls were recruited between March 2015 and July 2019. OP was diagnosed based on WHO criteria for diagnosis of OP as T score of bone mineral density (BMD) ≤-2.5; normal, as T score of BMD ≥-1. IGF-1 SNPs were genotyped by iPLEX Gold SNP genotyping. To be solid, related studies from PubMed, Embase, Cochrane, Web of science, and previous meta-analysis up until November 2020, along with our case-control study, were incorporated into a meta-analysis with criteria of significance using odds ratios (ORs) with corresponding 95% confidence intervals (CI) to evaluate risk factor of SNPs on OP. TSA was used to estimate the sample sizes required to achieve a conclusion.

Results

In dominant model of our case-control study, we found nonsignificant association of rs35767 [Adj-OR: 0.95 (95% CI: 0.56-1.60)], rs2288377 [Adj-OR: 1.15 (95% CI: 0.67-1.97)], and rs5742612 [Adj-OR: 1.07 (95% CI: 0.62-1.83)] with OP in postmenopausal females. However, integration of our case-control study and 3 published studies, rs35767 [OR: 1.24 (95% CI: 1.05-1.47)] showed a conclusively risk association with OP in postmenopausal females judged by TSA with 2267 Asians.

Conclusions

This study demonstrates a crucial sample to conclude that IGF-1 rs35767 is significantly associated with OP in postmenopausal women.

SUBMITTER: Su SL

PROVIDER: S-EPMC9876639 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature

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Publications

A case-control study coupling with meta-analysis elaborates decisive association between <i>IGF-1</i> rs35767 and osteoporosis in Asian postmenopausal females.

Su Sui-Lung SL Huang Yung-Hsun YH Chen Yu-Hsuan YH Ko Pi-Shao PS Su Wen W Wang Chih-Chien CC Lee Meng-Chang MC

Aging 20230103 1

<h4>Background</h4>Osteoporosis (OP) is prevalent in postmenopausal women. Several studies investigated the association between <i>IGF-1</i> polymorphisms and OP among postmenopausal females with conflicting outcomes.<h4>Objective</h4>To investigate whether the <i>IGF-1</i> (rs35767, rs2288377, rs5742612) were associated with OP in postmenopausal females.<h4>Methods</h4>In case-control study, 95 OP cases and 222 healthy controls were recruited between March 2015 and July 2019. OP was diagnosed b ...[more]

PMID: 36602528

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