Social trauma engages lateral septum circuitry to occlude social reward.

ABSTRACT: In humans, traumatic social experiences can contribute to psychiatric disorders¹. It is suggested that social trauma impairs brain reward function such that social behaviour is no longer rewarding, leading to severe social avoidance^2,3. In rodents, the chronic social defeat stress (CSDS) model has been used to understand the neurobiology underlying stress susceptibility versus resilience following social trauma, yet little is known regarding its impact on social reward^4,5. Here we show that, following CSDS, a subset of male and female mice, termed susceptible (SUS), avoid social interaction with non-aggressive, same-sex juvenile C57BL/6J mice and do not develop context-dependent social reward following encounters with them. Non-social stressors have no effe

SUBMITTER: Li L 

PROVIDER: S-EPMC9876792 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature