Undecaprenyl phosphate translocases confer conditional microbial fitness.

ABSTRACT: The microbial cell wall is essential for maintenance of cell shape and resistance to external stressors¹. The primary structural component of the cell wall is peptidoglycan, a glycopolymer with peptide crosslinks located outside of the cell membrane¹. Peptidoglycan biosynthesis and structure are responsive to shifting environmental conditions such as pH and salinity^2-6, but the mechanisms underlying such adaptations are incompletely understood. Precursors of peptidoglycan and other cell surface glycopolymers are synthesized in the cytoplasm and then delivered across the cell membrane bound to the recyclable lipid carrier undecaprenyl phosphate⁷ (C55-P, also known as UndP). Here we identify the DUF368-containing and DedA transmembrane protein fami

SUBMITTER: Sit B 

PROVIDER: S-EPMC9876793 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature