Antibody feedback regulates immune memory after SARS-CoV-2 mRNA vaccination.

ABSTRACT: Feedback inhibition of humoral immunity by antibodies was first documented in 1909¹. Subsequent studies showed that, depending on the context, antibodies can enhance or inhibit immune responses^2,3. However, little is known about how pre-existing antibodies influence the development of memory B cells. Here we examined the memory B cell response in individuals who received two high-affinity anti-SARS-CoV-2 monoclonal antibodies and subsequently two doses of an mRNA vaccine^4-8. We found that the recipients of the monoclonal antibodies produced antigen-binding and neutralizing titres that were only fractionally lower compared than in control individuals. However, the memory B cells of the individuals who received the monoclonal antibodies differed from those of

SUBMITTER: Schaefer-Babajew D 

PROVIDER: S-EPMC9876794 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature