Revealing genetic links of Type 2 diabetes that lead to the development of Alzheimer's disease.

ABSTRACT:

Background

A factor leading to Alzheimer's Disease (AD), portrayed by peripheral insulin resistance, is Type 2 diabetes mellitus (T2D). The likelihood of T2D cases would be at boosted danger in alternating AD cases has severe social consequences. Several genes have been detected via gene expression profiling or different techniques; despite the consideration of the utility of numerous of these genes stays insufficient.

Methods

This project is designed to uncover the mutual genomics motifs between AD and T2D via non-negative matrix factorization (NMF) of differentially expressed genes (DEGs) of T2D Mellitus of human cortical neurons of the neurovascular unit gene expression data. A rank factorization value is calculated by employing the combination of the NMF model with the u

SUBMITTER: Afzal M 

PROVIDER: S-EPMC9876837 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature