Health state utilities for beta-thalassemia: a time trade-off study.

ABSTRACT:

Background

Beta-thalassemia (BT) is an inherited blood disorder characterized by reduced levels of functional hemoglobin resulting in phenotypes ranging from clinically asymptomatic to severely anemic. Patients with BT may require lifelong regular blood transfusions supported by appropriate iron chelation therapy (ICT). This study aimed to determine how the UK general population values BT health states associated with differing transfusion burden and ICT.

Methods

Composite time trade-off (cTTO) methodology was employed to elicit health state utilities in BT. Relevant BT literature related to symptom and quality-of-life impact, including physical, functional, and emotional well-being, and safety profiles of BT treatments were considered when drafting health state descriptions

SUBMITTER: Martin AP 

PROVIDER: S-EPMC9876862 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature