The first comprehensive genomic characterization of rectal squamous cell carcinoma.

ABSTRACT:

Background

Rectal cancers represent 35% of colorectal cancers; 90% are adenocarcinomas, while squamous cell carcinoma accounts for 0.3% of them. Given its rarity, little is known concerning its pathogenesis, molecular profile and therapeutic management. The current treatment trend is to treat rectal squamous cell carcinoma by analogy to anal squamous cell carcinoma with definitive chemo-radiotherapy, setting aside surgery in case of local recurrence.

Methods

We performed an in-depth genomic analysis (next-generation sequencing, copy number variation, and human papilloma virus characterization) on 10 rectal squamous cell carcinoma samples and compared them in silico to those of anal squamous cell carcinoma and rectal adenocarcinoma.

Results

Rectal squamous cell carcino

SUBMITTER: Astaras C 

PROVIDER: S-EPMC9876866 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature