Influence of chemoradiation on the immune microenvironment of cervical cancer patients.

ABSTRACT:

Purpose

Cervical cancer remains a leading cause of cancer death in women. While immunotherapy has shown great success in combating cancer, the value of immunotherapy in cervical cancer is still only beginning to be explored. Thus, we performed a prospective analysis of patient blood and tumor samples at the beginning and end of conventional chemoradiation to assess changes in the immune cell and immunoreceptor compartments, and investigate if and when the addition of immunotherapy could be beneficial.

Methods

Patients with FIGO II-III cervical cancer receiving standard chemoradiation between January 2020 and December 2021 were included. We collected tumor and blood samples from patients before and at the end of therapy and analyzed immune cell composition and immune checkpoi

SUBMITTER: Herter JM 

PROVIDER: S-EPMC9876875 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature