Interferon signaling and hypercytokinemia-related gene expression in the blood of antidepressant non-responders.

ABSTRACT: Only 50% of patients with depression respond to the first antidepressant drug administered. Thus, biomarkers for prediction of antidepressant responses are needed, as predicting which patients will not respond to antidepressants can optimize selection of alternative therapies. We aimed to identify biomarkers that could predict antidepressant responsiveness using a novel data-driven approach based on statistical pattern recognition. We retrospectively divided patients with major depressive disorder into antidepressant responder and non-responder groups. Comprehensive gene expression analysis was performed using peripheral blood without narrowing the genes. We designed a classifier according to our own discrete Bayes decision rule that can handle categorical data. Nineteen genes showed diffe

SUBMITTER: Yamagata H 

PROVIDER: S-EPMC9876967 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature