Early time-restricted feeding improves high-density lipoprotein amount and function in nonhuman primates, without effects on body composition.

ABSTRACT:

Objective

Time-restricted feeding (TRF), whereby caloric intake is limited to a <12-hour window, is a potential regimen to ameliorate metabolic syndrome and cardiovascular disease (CVD) risk co-occurring with aging and with obesity. Early TRF (eTRF; early morning feeding followed by overnight fasting) times calorie consumption with hepatic circadian gene expression rhythms. Brief TRF trials demonstrate that high-density lipoprotein (HDL) cholesterol increases similar to diet/exercise interventions, which may impart beneficial CVD effects. Using a nonhuman primate (NHP) model, the efficacy of eTRF to raise HDL and increase plasma cholesterol efflux capacity (CEC) (primarily mediated by cholesterol efflux to HDL particles, a process that is inversely associated with CVD risk) was exa

SUBMITTER: Kavanagh K 

PROVIDER: S-EPMC9877107 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature