Nonselective beta blockers, hepatic decompensation, and mortality in cirrhosis: A national cohort study.

ABSTRACT:

Background and aims

Little is known about the effectiveness of nonselective beta blockers (NSBBs) in preventing hepatic decompensation in routine clinical settings. We investigated whether NSBBs are associated with hepatic decompensation or liver-related mortality in a national cohort of veterans with Child-Turcotte-Pugh (CTP) A cirrhosis with no prior decompensations.

Approach and results

In an active comparator, new user (ACNU) design, we created a cohort of new users of carvedilol ( n = 123) versus new users of selective beta blockers (SBBs) ( n = 561) and followed patients for up to 3 years. An inverse probability treatment weighting (IPTW) approach balanced demographic and clinical confounders. The primary analysis simulated intention-to-treat ("pseudo-ITT") with IPTW-a

SUBMITTER: Serper M 

PROVIDER: S-EPMC9877112 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature