Risk factors and prognostic significance of platelet count abnormalities in children with HIV infection on antiretroviral therapy.

ABSTRACT:

Objectives

To establish the incidence, risk factors and correlation with survival of thrombocytopenia and thrombocytosis (T/T) among children with HIV infection (CWH).

Design

A retrospective nested case control study of patients 0-18 years in five Baylor International Pediatric AIDS Initiative (BIPAI) centers in sub-Sahara Africa, 2004-2014.

Methods

Clinical and laboratory variables including complete blood counts (CBC) were extracted from the BIPAI electronic medical record system. Incident cases of T/T were identified and frequency-matched on follow-up time with controls with normal platelets. We calculated the prevalence and incidence density of T/T and used conditional logistic regression to evaluate their association with selected clinical variables. We construct

SUBMITTER: Lubega J 

PROVIDER: S-EPMC9877116 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature