Place cells are nonrandomly clustered by field location in CA1 hippocampus.

ABSTRACT: A challenge in both modern and historic neuroscience has been achieving an understanding of neuron circuits, and determining the computational and organizational principles that underlie these circuits. Deeper understanding of the organization of brain circuits and cell types, including in the hippocampus, is required for advances in behavioral and cognitive neuroscience, as well as for understanding principles governing brain development and evolution. In this manuscript, we pioneer a new method to analyze the spatial clustering of active neurons in the hippocampus. We use calcium imaging and a rewarded navigation task to record from 100 s of place cells in the CA1 of freely moving rats. We then use statistical techniques developed for and in widespread use in geographic mapping studies,

SUBMITTER: Wirtshafter HS 

PROVIDER: S-EPMC9877199 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature