Paced breathing and respiratory movement responses evoked by bidirectional constant current stimulation in anesthetized rabbits.

ABSTRACT: Objective: Diaphragm pacing (DP) is a long-term and effective respiratory assist therapy for patients with central alveolar hypoventilation and high cervical spinal cord injury. The existing DP system has some limitations, especially high price, inconvenience preoperative evaluation methods and diaphragm fatigue easily. Our objective was to develop a DP system and evaluated reliability through hardware testing and animal experiments. Methods: A DP system with bidirectional constant current was designed, manufactured and tested. Effects of a wide range of stimulus amplitudes (range: .5-2.5 mA) and frequencies (range: 10-250 Hz) on airflow and corresponding inspired volume were investigated during DP. Differences in airflow characteristics under various stimulation parameters w

SUBMITTER: Gu X 

PROVIDER: S-EPMC9877234 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature