Longitudinal assessment of structural phenotype in Brugada syndrome using cardiac magnetic resonance imaging.

ABSTRACT:

Background

Despite historically being considered a channelopathy, subtle structural changes have been reported in Brugada syndrome (BrS) on histopathology and cardiac magnetic resonance (CMR) imaging. It is not known if these structural changes progress over time.

Objective

The study sought to assess if structural changes in BrS evolve over time with serial CMR assessment and to investigate the utility of parametric mapping techniques to identify diffuse fibrosis in BrS.

Methods

Patients with a diagnosis of BrS based on international guidelines and normal CMR at least 3 years prior to the study period were invited to undergo repeat CMR. CMR images were analyzed de novo and compared at baseline and follow-up.

Results

Eighteen patients with BrS (72% men; mean age

SUBMITTER: Isbister JC 

PROVIDER: S-EPMC9877394 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature