Genetic and clinical profiles of 160 papillary thyroid cancers with lateral neck lymph node metastasis.

ABSTRACT:

Background

Lymph node metastasis is widespread in papillary thyroid cancer (PTC). Patients are more vulnerable than those with central lymph node metastasis if they have lateral neck lymph node metastasis (LLNM). There are few researches focus on the correlation between clinical characteristics and genetic profile of PTC with LLNM. In this study, we aimed to analyze the clinical and genetic features of PTC with LLNM.

Methods

A total of 160 primary tumor samples derived from PTC patients with LLNM were involved. Targeted next-generation sequencing was carried out on all samples with 57 known thyroid-cancer-related genes. The associations between genomic alternations and clinical characteristics of PTC with LLNM were statistically evaluated.

Results

The median age of pa

SUBMITTER: Fang Y 

PROVIDER: S-EPMC9877400 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature