Intestinal metabolites and the risk of autistic spectrum disorder: A two-sample Mendelian randomization study.

ABSTRACT:

Background

Observational studies have reported a strong association between autistic spectrum disorder (ASD) and intestinal metabolites. However, it is unclear whether this correlation is causally or violated by confounding or backward causality. Therefore, this study explored the potential causal relationship between intestinal metabolites and dependent metabolites on ASD.

Methods

We used a two-sample Mendelian random analysis and selected variants closely related to intestinal flora-dependent metabolites as instrumental variables. MR-Egger, inverse variance weighted (IVW), MR-PRESSO, maximum likelihood, and weighted median were performed to reveal their causal relationships. Ten metabolites were studied, which included trimethylamine-N-oxide, betaine, carnitine, choline, g

SUBMITTER: Liu D 

PROVIDER: S-EPMC9877426 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature