Meiotic DNA exchanges in C. elegans are promoted by proximity to the synaptonemal complex.

ABSTRACT: During meiosis, programmed double-strand DNA breaks are repaired to form exchanges between the parental chromosomes called crossovers. Chromosomes lacking a crossover fail to segregate accurately into the gametes, leading to aneuploidy. In addition to engaging the homolog, crossover formation requires the promotion of exchanges, rather than non-exchanges, as repair products. However, the mechanism underlying this meiosis-specific preference is not fully understood. Here, we study the regulation of meiotic sister chromatid exchanges in Caenorhabditis elegans by direct visualization. We find that a conserved chromosomal interface that promotes exchanges between the parental chromosomes, the synaptonemal complex, can also promote exchanges between the sister chromatids. In both cases,

SUBMITTER: Almanzar DE 

PROVIDER: S-EPMC9877436 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature