Acrolein-inducing ferroptosis contributes to impaired peripheral neurogenesis in zebrafish.

ABSTRACT:

Introduction

Diabetes mellitus (DM) is associated with physiological disorders such as delayed wound healing, diabetic retinopathy, diabetic nephropathy, and diabetic peripheral neuropathy (DPN). Over 50% of diabetic patients will develop DPN, characterized by motor dysfunction and impaired sensory nerve function. In a previous study, we have uncovered acrolein (ACR) as an upstream initiator which induced impaired glucose homeostasis and microvascular alterations in zebrafish. Whether ACR has specific effects on peripheral neurogenesis and mediates DPN, is still waiting for clarification.

Methods

To evaluate the function of ACR in peripheral nerve development, in vivo experiments were performed in Tg(hb9:GFP) zebrafish. In addition, a series of rescue experimen

SUBMITTER: Qi H 

PROVIDER: S-EPMC9877442 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature