A morphological study of the shape of the corpus callosum in normal, schizophrenic and bipolar patients.

ABSTRACT: Abnormalities in the morphology of the corpus callosum have been found to be involved in cognitive impairments or abnormal behaviour in patients with mental disorders such as schizophrenia and bipolar disorder. The present study investigated morphological shape differences of the corpus callosum in a large cohort of 223 participants between normal, schizophrenic and bipolar patients on MRI scans, CT scans and cadaver samples. Healthy samples were compared to a mental disorder population sample to determine morphological shapes variations associated with schizophrenia and bipolar disorder. Landmark-based methodology was used to contour the corpus callosum shape that served as standard positions to allow for radial and thickness partitioning in order to determine shape variations within the

SUBMITTER: Vermeulen CL 

PROVIDER: S-EPMC9877476 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature