Akkermansia and its metabolites play key roles in the treatment of campylobacteriosis in mice.

ABSTRACT:

Introduction

Campylobacter jejuni (C. jejuni) is a common food-borne bacterial pathogen that can use the host's innate immune response to induce the development of colitis. There has been some research on the role of normal intestinal flora in C. jejuni-induced colitis, but the mechanisms that play a central role in resistance to C. jejuni infection have not been explored.

Methods

We treated Campylobacter jejuni-infected mice with fecal microbiota transplantation (FMT), oral butyric acid and deoxycholic acid in a controlled trial and analyzed the possible mechanisms of treatment by a combination of chromatography, immunohistochemistry, fluorescence in situ hybridization, 16s rRNA gene, proteomics and western blot techniques.

Results

We firs

SUBMITTER: Jiang L 

PROVIDER: S-EPMC9877526 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature