Predicting DNA-binding protein and coronavirus protein flexibility using protein dihedral angle and sequence feature.

ABSTRACT: The flexibility of protein structure is related to various biological processes, such as molecular recognition, allosteric regulation, catalytic activity, and protein stability. At the molecular level, protein dynamics and flexibility are important factors to understand protein function. DNA-binding proteins and Coronavirus proteins are of great concern and relatively unique proteins. However, exploring the flexibility of DNA-binding proteins and Coronavirus proteins through experiments or calculations is a difficult process. Since protein dihedral rotational motion can be used to predict protein structural changes, it provides key information about protein local conformation. Therefore, this paper introduces a method to improve the accuracy of protein flexibility prediction, DihProFle (Pr

SUBMITTER: Wang W 

PROVIDER: S-EPMC9877568 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature