Observational case-control study of small-fiber neuropathies, with regards on smoking and vitamin D deficiency and other possible causes.

ABSTRACT:

Introduction

Small fiber neuropathies (SFNs) are disorders of skin nerve endings inducing pruritus, burning pain, numbness, and paresthesia. The aims of this study were to search for putative etiologies of SFN and their occurrence in a cohort of patients and to compare patients with SFN to a group of patients without SFN to highlight potential factors associated with SFN.

Methods

This study was observational, retrospective, and monocentric. All patients with symptoms of SFN who underwent skin biopsies with intraepidermal nerve density counts were included. Patients with a count lower than 5 percentiles were considered to be in the SFN group. Other patients were considered to be the control group.

Results

A total of 162 patients with SFN and 161 controls were included.

SUBMITTER: Fouchard M 

PROVIDER: S-EPMC9877604 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature