Association between night shift work and methylation of a subset of immune-related genes.

ABSTRACT:

Introduction

Night shift (NS) work has been associated with an increased risk of different conditions characterized by altered inflammatory and immune responses, such as cardio-metabolic and infectious diseases, cancer, and obesity. Epigenetic modifications, such as DNA methylation, might mirror alterations in biological processes that are influenced by NS work.

Methods

The present study was conducted on 94 healthy female workers with different working schedules and aimed at identifying whether NS was associated with plasmatic concentrations of the inflammatory proteins NLRP3 and TNF-alpha, as well as with DNA methylation levels of ten human endogenous retroviral (HERV) sequences, and nine genes selected for their role in immune and inflammatory processes. We also explored t

SUBMITTER: Ferrari L 

PROVIDER: S-EPMC9877629 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature