Haplotypic variants of COVID-19 related genes are associated with blood pressure and metabolites levels.

ABSTRACT: The genetic association of coronavirus disease 2019 (COVID-19) with its complications has not been fully understood. This study aimed to identify variants and haplotypes of candidate genes implicated in COVID-19 related traits by combining the literature review and pathway analysis. To explore such genes, the protein-protein interactions and relevant pathways of COVID-19-associated genes were assessed. A number of variants on candidate genes were identified from Genome-wide association studies (GWASs) which were associated with COVID-19 related traits (p ˂ 10^-6 ). Haplotypic blocks were assessed using haplotypic structures among the 1000 Genomes Project (r²  ≥ 0.8, D' ≥ 0.8). Further functional analyses were performed on the selected variants. The results demonstrated

SUBMITTER: Gholami M 

PROVIDER: S-EPMC9877746 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature