The intensity of anticoagulant dosing in hospitalized patients with COVID-19: An observational, comparative effectiveness study.

ABSTRACT:

Background

The question of anticoagulant dosing in hospitalized patients with coronavirus disease-2019 (COVID-19) is unresolved, with randomized trials showing mixed results and heterogeneity of treatment effects for in-hospital death.

Objective

To examine the association between the intensity of anticoagulation and clinical outcomes in hospitalized patients with COVID-19.

Design, setting and participants

Retrospective cohort study of patients with COVID-19 and respiratory impairment who were hospitalized between 3/1/2020-12/31/2020 in two Kaiser Permanente regions.

Exposure and main outcome

We fit propensity score models using categorical regression to estimate the probability of receiving standard prophylactic, intermediate, or full-dose anticoagulation begin

SUBMITTER: Myers LC 

PROVIDER: S-EPMC9877905 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature