Insight into the role of clathrin-mediated endocytosis inhibitors in SARS-CoV-2 infection.

ABSTRACT: Emergence of SARS-CoV-2 variants warrants sustainable efforts to upgrade both the diagnostic and therapeutic protocols. Understanding the details of cellular and molecular basis of the virus-host cell interaction is essential for developing variant-independent therapeutic options. The internalization of SARS-CoV-2, into lung epithelial cells, is mediated by endocytosis, especially clathrin-mediated endocytosis (CME). Although vaccination is the gold standard strategy against viral infection, selective inhibition of endocytic proteins, complexes, and associated adaptor proteins may present a variant-independent therapeutic strategy. Although clathrin and/or dynamins are the most important proteins involved in CME, other endocytic mechanisms are clathrin and/or dynamin independent and rely o

SUBMITTER: Alkafaas SS 

PROVIDER: S-EPMC9877911 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature