Immune correlates of protection by vaccine against SARS-CoV-2 in patients with chronic lymphocytic leukaemia.

ABSTRACT: In chronic lymphocytic leukaemia (CLL) the efficacy of SARS-CoV-2 vaccination remains unclear as most studies have focused on humoral responses. Here we comprehensively examined humoral and cellular responses to vaccine in CLL patients. Seroconversion was observed in 55.2% of CLL with lower rate and antibody titres in treated patients. T-cell responses were detected in a significant fraction of patients. CD4⁺ and CD8⁺ frequencies were significantly increased independent of serology with higher levels of CD4⁺ cells in patients under a Bruton tyrosine kinase (BTK) or a B-cell lymphoma 2 (BCL-2) inhibitor. Vaccination skewed CD8⁺ cells towards a highly cytotoxic phenotype, more pronounced in seroconverted patients. A high proportion of patients show

SUBMITTER: Sorcini D 

PROVIDER: S-EPMC9878216 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature