Use of fluorescence imaging to optimize location of tissue sampling in hard-to-heal wounds.

ABSTRACT:

Introduction

Wound microflora in hard-to-heal wounds is invariably complex and diverse. Determining the interfering organisms(s) is therefore challenging. Tissue sampling, particularly in large wounds, is subjective and, when performed, might involve swabbing or biopsy of several locations. Fluorescence (FL) imaging of bacterial loads is a rapid, non-invasive method to objectively locate microbial hotspots (loads >10⁴ CFU/gr). When sampling is deemed clinically necessary, imaging may indicate an optimal site for tissue biopsy. This study aimed to investigate the microbiology of wound tissue incisional biopsies taken from sites identified by FL imaging compared with sites selected by clinical judgment.

Methods

A post hoc analysis of the 350-patient FLAAG wou

SUBMITTER: Serena TE 

PROVIDER: S-EPMC9878329 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature